The consistency of a second-order version of Morley’s Theorem on the number of countable models was proved in [EHMT23] with the aid of large cardinals. We here dispense with them.

The public largely supports the use of animals in biomedical research, but only if they are sure that the animals are treated humanely. The scientific community has provided these assurances. Is this a truthful claim? I argue that when examined systematically, the claim that animals in research are treated humanely is not truthful by any existing definition of the word. This article does not argue for or against the morality of using animals in research; rather, the reasoning set forth herein (...) argues that in this use of animals, the scientific community is not being truthful to the public. (shrink)

In this paper, I present an analysis of those aspects of Karl Polanyi's social and political thought that relate to environmentalism and ‘green’ politics today. I discuss whether or not he prefigured the degrowth movement, before focusing on his understanding of the New Deal (1933–1939). At the time of writing, the prospect appears likely of a return, at a global scale, of economic slump, mass unemployment and ecological crisis, the background conditions to which Franklin D. Roosevelt's New Deal (...) was responding on the national scale. The paper concludes by drawing lessons from this comparison for possible Green New Deals. (shrink)

This remarkable collection contains Isaiah Berlin's appreciations of seventeen people of unusual distinction in the intellectual or political world, sometimes both. The names of many of them are familiar: Winston Churchill, Franklin D. Roosevelt, Chaim Weizmann, Albert Einstein, and others. With the exception of Roosevelt, he met them all and knew many of them well. For this expanded edition, four new portraits have been added, including those of Virginia Woolf and Edmund Wilson. This volume also contains a (...) vivid and moving account of Berlin's meetings in Russia with Boris Pasternak and Anna Akhmatova in 1945 and 1956. Perhaps the most fascinating of these "personal impressions" is found in the epilogue, where Berlin describes the three strands in his own personality: Russian, English, and Jewish. (shrink)

To his credit, Chomsky puts them all on his website, whether it’s The New Yorker describing him as “the devil’s accountant†and “one of the greatest minds of the 20th centuryâ€, or The Nation, which lampooned him as “a very familiar kind of academic hack†whose career has been “the product of a combination of self-promotion, abuse of detractors, and the fudging of his findingsâ€. He stands accused of asserting that every US President since Franklin D Roosevelt should (...) have been impeached as war criminals; of supporting the murderous Pol Pot regime in Cambodia; and of comparing Israel to the Third Reich. (shrink)

In this article I argue that the Farm Security Administration (FSA) photographs of the Greenbelt Town program in the late 1930s function beyond the goals for which the FSA photographs are typically known.1 The FSA photographs documented scenes of urban and rural poverty during the Great Depression to make the case for supporting President Franklin D. Roosevelt’s New Deal policies. In the midst of the Great Depression, the U.S. government planned and built three Greenbelt towns with a utopian (...) vision of modern living for displaced farmers and the urban poor. I argue that within the larger collection of FSA photographs, which typically portray images of American struggle and resilience, exists a group of photographs .. (shrink)

In 1944, American Polonia consisted of two separate social groups. The first one was the so-called “old Polonia”. This group was significantly assimilated into America’s culture and way of life, and had strong self-help organizations. The second group, “new Polonia”, was formed of wartime émigrés, mainly with intellectual backgrounds. They experienced at first hand the anti-human policies of the Nazi and Soviet systems.In the Polish American Congress, founded in 1944 by representatives of both groups, there was great concern about the (...) policies of President Franklin D. Roosevelt. The fear was that these policies would allow Stalin, by a method of fait accompli, to introduce the Soviet system in all countries “liberated” by the Red Army. Old Polonia was under the influence of the US Administration and, despite reservations, supported the approach of Polish Prime Minister Stanisław Mikołajczyk who was committed to finding a Polish-Soviet compromise. Such a compromise turned out to be impossible because of Stalin’s demands. Firstly, nearly 50% of the pre-war territory of Poland was to be ceded to the Soviet Union. Secondly, fundamental changes were to be made in the government leadership of the Polish satellite state.New Polonia, which in 1942 formed the National Committee of Americans of Polish Descent, had a strong intellectual group. They warned the Polish American Congress and the US Administration against conceding to Stalin’s demands. From the perspective of the Sixtieth Anniversary of the Warsaw Uprising, their evaluation of Stalin’s policy has turned out to be correct.There was also a small group of Polish American activists centered around Professor Oskar Lange and the eminent poet Julian Tuwim, who belonged to the so-called Kościuszko League. During the Warsaw Uprising they were willing to accept Stalin’s demands and in connection with this supported the policies of the Polish Committee for National Liberation (a pro-communist coalition).The overwhelming majority of American Polonia was involved in unmasking false information about the Warsaw Uprising in the American press. They signed petitions to the President and Secretary of State. They collected money. They organized religious and patriotic meetings at which true information about the Warsaw Uprising was presented. (shrink)

Upon entering the White House in 1933, President Franklin D. Roosevelt faced an ailing economy in the throes of the Great Depression and rushed to transform the country through recovery programs and legislative reform. By 1934, he began to send professional photographers to the state of West Virginia to document living conditions and the effects of his New Deal programs. The photographs from the Farm Security Administration Project not only introduced “America to Americans,” exposing a continued need for (...) government intervention, but also captured powerful images of life in rural and small town America.New Deal Photographs of West Virginia, 1934-1943 presents images of the state's northern and southern coalfields, the subsistence homestead projects of Arthurdale, Eleanor, and Tygart Valley, and various communities from Charleston to Clarksburg and Parkersburg to Elkins. With over one hundred and fifty images by ten FSA photographers, including Walker Evans, Marion Post Wolcott, Arthur Rothstein, and Ben Shahn, this collection is a remarkable proclamation of hardship, hope, endurance, and, above all, community. These photographs provide a glimpse into the everyday lives of West Virginians during the Great Depression and beyond. (shrink)

This book focuses on the political thought of American statesmen. These statesmen have had consistent and comprehensive views of the good of the country and their actions have been informed by those views. The editors argue that political life in America has been punctuated by three great crises in its history-the crisis of the Founding, the crisis of the House Divided, and the crisis of the Great Depression. The Second World War was a crisis not just for America but for (...) the whole of Western Civiliation and, in the wake of that war, a new crisis arose which came to be called the "Cold War." Just when that gave the appearance of being resolved, the world reached a new juncture, a new crisis, which Samuel P. Huntington dubbed the "clash of civiliations." The statesmen having political responsibility in confronting the first three crises in America's history came as close to philosophic grasp of the problems of liberal democracy as one could demand from those embroiled in the active resolution of events. Their reflection of political philosophy in the full sense informed their actions. Since we cannot confidently explain the future, Aristotle warned us to call no man happy while he still lives. Thus the book, in its third edition, keeps to its settled pattern of dealing with settled matters. The preface to the third edition confronts the three later crises and, to the extent consistent with truth, attempts to relate them to the first three. Morton J. Frisch was professor emeritus of political science at Northern Illinois University. He was the author or editor of several books, including Selected Writings and Speeches of Alexander Hamilton; Alexander Hamilton and the Political Order; and Franklin D. Roosevelt: The Contribution of the New Deal to American Political Thought and Practice. Richard G. Stevens retired from National Defense University as professor of political science in 1994. Since then he has taught as an adjunct professor of government at American University. He is co-editor with Matthew J. Franck of Sober as a Judge: The Supreme Court and Republican Liberty, and the author of The American Constitution and Its Provenance; Reason and History in Judicial Judgment: Felix Frankfurter and Due Process; and Political Philosophy: An Introduction. (shrink)

Dating back to the 1930s, President Franklin D. Roosevelt argued that workers were entitled to a wage that allowed them to enjoy a decent standard of living—a conviction that led the president to propose the first federally-mandated minimum wage. Mr. Roosevelt’s proposal was met with highly partisan resistance in congress and the courts—reactions not different in kind from the highly partisan resistance former President Obama experienced in his proposal to increase the federal minimum wage from its current (...) level of $7.25 per hour. Reflecting President Roosevelt’s convictions, it is clear that many low wage workers today are not, and cannot, enjoying a decent standard of living at current minimum wage levels. Further, many of the economic arguments raised in opposition to increasing the minimum wage have been thoroughly discredited: empirical evidence suggests that increased minimum wages would not lead to dramatic spikes in unemployment, massive substitutions of capital for labor, business closings, and significantly increased consumer prices. However, as compelling as arguments for increasing the minimum wage may be, the reality is that this may not be sufficient to alleviate the plight of low income workers, particularly given the political nature of minimum wage adjustments. Indeed, it may be time to shift the national focus away from the minimum wage to an emphasis on viable living wage legislation, a proposition consistent with the social justice perspective of contemporary ethicists. (shrink)

The fiftieth anniversary of the death of President Franklin Delano Roosevelt arrived only months after the 1994 U.S. elections brought to power conservative Republican congressional majorities determined to reverse key legacies of Roosevelt's New Deal. At this juncture of special poignancy for many of those assembled at the “Little White House” in Warm Springs, Georgia on April 12, 1995, President Bill Clinton offered remarks on “Remembering Franklin D. Roosevelt.” “Like our greatest presidents,” Clinton eulogized, (...) class='Hi'>Roosevelt “showed us how to be a nation in time of great stress” and “taught us again and again that our government could be an instrument of democratic destiny.”. (shrink)

The Man Who Tapped the Secrets of the Universe (1946) by Glenn Clark is a work of biography and philosophy, exploring the life and ideas of the versatile artist, writer, and philosopher Walter Russell. New Thought writer and professor Glenn Clark (b. 1882, d. 1956) was a fervent believer in the power of prayer and the Light of God to reveal the secrets of the universe. As he explains in Chapter One: We Go Seeking, he had been searching "...for a (...) man who has discovered the universal law which lies back of the Sermon on the Mount, and who consciously uses that law with full awareness of its meaning, and full obedience to its principles." He believed that he had found that man in Walter Russell. Walter Russell (b. 1871, d. 1963) was a man who seemed preternaturally adept at everything he wished to try. After being removed from school at the age of nine and sent to work at a dry goods store, he worked a number of low-paying jobs. But he had "absolute faith...that anything can come to one who trusts to the unlimited help of the Universal Intelligence that is within so long as one works within the law and always gives more to others than they expect, and does it cheerfully and courteously." Throughout his life, he found success as a musician, painter, sculptor, writer, ice skater, philosopher, and lecturer. He was commissioned to sculpt a 28-figure Mark Twain Memorial just a few years after he began sculpting. And in 1943, President Franklin D. Roosevelt asked him to sculpt the Four Freedoms Monument. He designed several buildings in New York City and invented the cooperative ownership model (aka the co-op). And most of these pursuits were undertaken with no formal education. By the time Clark met with Russell, he had achieved success in his artistic, literary, architectural, physical, and even scientific pursuits. So when Clark was searching for a man who knew the secrets of the universe and was referred to Russell on more than one occasion, he knew that he had to meet him. Large portions of the book, particularly in the chapters We Meet the Man, We Meet the Man of Action, and The Five Laws of Success, are presented as an interview with Russell, giving us insight into his beliefs straight from the source. "Every successful man or great genius has three particular qualities in common," he says. "The most conspicuous of these is that they all produce a prodigious amount of work. The second is that they never know fatigue. And the third is that their minds grow more brilliant as they grow older, instead of less brilliant. Great men's lives begin at forty, where the mediocre man's life ends. The genius remains an ever-flowing fountain of creative achievement until the very last breath he draws." At the heart of Russell's philosophy is a belief that every man "has consummate genius within him. Some appear to have it more than others only because they are aware of it more than others are, and the awareness or unawareness of it is what makes each one of them into masters or holds them down to mediocrity..." To know that we have genius inside of us, and to have absolute faith in our inner voice and in the Universe, is to unlock that genius. Through the story of Russell's brilliant life and his Five Personal Laws of Success (humility, reverence, inspiration, deep purpose, and joy), the reader gets a plain-language example of genius-in-action. He demonstrated his great energy, lack of fatigue, and "ever-flowing fountain" of genius throughout his long life, maintaining his creativity until his death in 1963 at the age of 92. (shrink)

_Confronting American Labor_ traces the development of the American left, from the Depression era through the Cold War, by examining four representative intellectuals who grappled with the difficult question of labor’s role in society. Since the time of Marx, leftists have raised over and over the question of how an intelligentsia might participate in a movement carried out by the working class. Their modus operandi was to champion those who suffered injustice at the hands of the powerful. From the late (...) nineteenth through much of the twentieth century, this meant a focus on the industrial worker. The Great Depression was a time of remarkable consensus among leftist intellectuals, who often interpreted worker militancy as the harbinger of impending radical change. While most Americans waited out the crisis, listening to the assurances of President Franklin D. Roosevelt, the Marxian left was convinced that the crisis was systemic. Intellectuals who came of age during the Depression developed the view that the labor movement in America was to be the organizing base for a proletariat. Moreover, many came from working-class backgrounds that contributed to their support of labor. World War II and the resultant economic recovery shattered this coherence on the left. How did radicals opposed to capitalism deal with a labor movement that was very successful in terms of membership and power but clearly capitalist in its orientation? Coker describes the marked ambivalence and confusion of the intellectual left in the postwar years—a period of frustration brought on by a misreading of labor militancy during the 1930s and an unsuccessful search for a radical proletarian movement. The result was a politically and intellectually weakened left for decades to come. C_onfronting American Labor_ examines four individuals who represent a cross section of postwar radicalism. Each came of age on the socialist left, expecting that an anticapitalist movement would emerge from the ranks of labor. Seymour Martin Lipset and C. Wright Mills were professional sociologists. Sidney Lens spent his early life working within the labor movement before becoming a political commentator for a variety of leftist magazines and journals in the postwar era. Historian Herbert Gutman helped to create a “new labor history” that reflected broader transformations within the intellectual left. In tracing their various approaches to the problem of labor, C_onfronting American Labor_ explores the diverse nature of the postwar left. This important work will be of value to anyone interested in labor, class, and American thought. (shrink)

When our measurement instruments sample from only a subspace of the domain that we are seeking to understand, or when they sample with uneven sampling density from the target domain, the resulting data will be affected by a selection effect. If we ignore such selection effects, our conclusions may suffer from selection biases. A classic example of selection bias is the election poll taken by the Literary Digest in 1936. On the basis of a large survey, the Digest predicted that (...) Alf Langdon, the Republican presidential candidate, would win by a large margin. But the actual election resulted in a landslide for the incumbent, Franklin D. Roosevelt. How could such a large sample yield such a wayward prediction? The Digest, it turned out, had harvested the addresses for its survey mainly from telephone books and motor vehicle registries. This introduced a strong selection effect. The poor of the depression era, a group that disproportionally supported Roosevelt, often did not have phones or cars. Observation selection effects are an especially subtle kind of selection effect that is introduced not by limitations in our measurement apparatuses but by the fact that all evidence is preconditioned on the existence of an observer to “have” the evidence and to build the instruments in the first place. Observation selection effects have only quite recently become the subject of systematic study. As well as being of philosophical interest, they are important in many scientific areas, including cosmology, parts of evolution theory, and the foundations of thermodynamics and quantum theory. There are also interesting applications to the search for extraterrestrial life and questions such as whether we might be living in a computer simulation created by an advanced civilization.. (shrink)

In 2019, protests in the streets of Algeria and Sudan, Lebanon and Iraq brought back the fragrance of the Jasmine revolution. Can the pendulum swing back towards democracy and human rights in the M...

By utilizing the topological concept of pseudocompactness, we simplify and improve a proof of Caicedo, Dueñez, and Iovino concerning Terence Tao's metastability. We also pinpoint the exact relationship between the Omitting Types Theorem and the Baire Category Theorem by developing a machine that turns topological spaces into abstract logics.

Given a space in an elementary submodel M of H, define XM to be X∩M with the topology generated by . It is established, using anti-large-cardinals assumptions, that if XM is compact and its regular open algebra is isomorphic to that of a continuous image of some power of the two-point discrete space, then X=XM. Assuming in addition, the result holds for any compact XM satisfying the countable chain condition.

The currently leading cognitive theory of consciousness, Global Workspace Theory,1,2 postulates that the primary functions of consciousness include a global broadcast serving to recruit internal resources with which to deal with the current situation and to modulate several types of learning. In addition, conscious experiences present current conditions and problems to a "self" system, an executive interpreter that is identifiable with brain structures like the frontal lobes and precuneus.1Be it human, animal or artificial, an autonomous agent3 is said to be (...) functionally conscious if its control structure (mind) implements Global Workspace Theory and the LIDA Cognitive Cycle, which includes unconscious memory and control functions needed to integrate the conscious component of the system. We would therefore consider humans, many animals4 and even some virtual or robotic agents5,6 to be functionally conscious. Such entities may approach phenomenal consciousness, as found in human and other biological brains, as additional brain-like features are added.Here we argue that adding mechanisms to produce a stable, coherent perceptual field7 in a LIDA controlled mobile robot might provide a small but significant step toward phenomenal consciousness in machines.>8 We also propose that implementing several of the various notions of self in such a LIDA controlled robot may well prove another step toward phenomenal consciousness in machines. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Incoherence of Determining Death by Neurological Criteria: A Commentary on Controversies in the Determination of Death, A White Paper by the President’s Council on Bioethics*Franklin G. Miller** (bio) and Robert D. Truog (bio)Traditionally the cessation of breathing and heart beat has marked the passage from life to death. Shortly after death was determined, the body became a cold corpse, suitable for burial or cremation. Two technological changes (...) in the second half of the twentieth century prompted calls for a new, or at least expanded, definition of death: the development of intensive care medicine, especially the use of mechanical ventilators, and the advent of successful transplantation of vital organs. Patients with profound neurological damage, leaving them incapable of breathing on their own and in an irreversible coma, could be maintained for some period of time with the aid of mechanical ventilation. The situation of these patients posed two ethical questions. Is it appropriate to stop life-sustaining treatment? If so, is it acceptable to retrieve vital organs for transplantation to save the lives of others before stopping treatment?In 1968, the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death proposed that death could be determined on the basis of neurological criteria, thus providing a positive answer to these two questions (Ad Hoc Committee 1968). According to the position of this committee, patients diagnosed with the cessation of brain function are dead, despite the fact that they breathe and circulate blood with the aid of mechanical ventilation. [End Page 185] Because they are dead, it is appropriate, indeed imperative, to stop mechanical ventilation. And because they are dead, it becomes ethical to procure vital organs for transplantation before stopping what otherwise would be life-sustaining treatment. Remarkably, this innovative neurological determination of death became, with little debate or controversy, the established position in medical ethics and the law throughout the United States.The Harvard Committee articulated the diagnosis of “irreversible coma,” but merely asserted that this condition constituted death. No explanatory rationale was provided. It fell to the President’s Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research to provide an authoritative rationale in its 1981 report, Defining Death. The second paragraph of the report set the stage as follows: “The question addressed here is not inherently difficult or complicated. Simply, it is whether the law ought to recognize new means for establishing that the death of a human being has occurred” (President’s Commission 1981, p. 3). The Commission claimed that “death is a unitary phenomenon” (p. 7) and that the determination of death by neurological criteria, in terms of the absence of all brain function, is consistent with the traditional conception of death as the cessation of vital functioning of the organism as a whole. The key issue is the integrative functioning of the human organism, which ceases to exist, according to the Commission, when the whole brain, including higher cortical areas and the brain stem, fails to function. Although “brain-dead” patients do not appear to be dead—i.e., the reality of their death is “masked” by the activity of mechanical ventilation—the patient’s body has irreversibly lost all capacity for integrative functioning. In the words of the Commission: “When artificial means of support mask this loss of integration as measured by the old methods [cessation of respiration and heart beat], brain-oriented criteria and tests provide a new window on the same phenomenon” (p. 33). The President’s Commission was instrumental in developing and establishing “The Uniform Definition of Death Act”: “An individual who has sustained either (1) irreversible cessation of circulatory and respiratory functions, or (2) irreversible cessation of all functions of the entire brain, including the brain stem, is dead” (p. 2).Although the question posed by the President’s Commission was easy to articulate, the answer, over time, has proved complicated and controversial. The coherence and cogency of determining death by neurological criteria has been challenged. Various experts have demonstrated that “brain-dead” patients maintained on mechanical ventilation display a range of vital, integrative, functioning, which conflicts with the judgment that they are dead (Truog and... (shrink)

Conventional medical ethics and the law draw a bright line distinguishing the permitted practice of withdrawing life-sustaining treatment from the forbidden practice of active euthanasia by means of a lethal injection. When clinicians justifiably withdraw life-sustaining treatment, they allow patients to die but do not cause, intend, or have moral responsibility for, the patient's death. In contrast, physicians unjustifiably kill patients whenever they intentionally administer a lethal dose of medication. We argue that the differential moral assessment of these two practices (...) is based on a series of moral fictions – motivated false beliefs that erroneously characterize withdrawing life-sustaining treatment in order to bring accepted end-of-life practices in line with the prevailing moral norm that doctors must never kill patients. When these moral fictions are exposed, it becomes apparent that conventional medical ethics relating to end-of-life decisions is radically mistaken. (shrink)

Accepted medical practice already violates the dead donor rule. Explicitly jettisoning the rule—allowing vital organs to be extracted, under certain conditions, from living patients—is a radical change only at the conceptual level. But it would expand the pools of eligible organ donors.

Drawing on a recent case report of a pregnant, brain‐dead woman who gave birth to a healthy child after over seven months of intensive care treatment, this essay rejects the established doctrine in medicine that brain death constitutes the biological death of the human being. The essay describes three policy options with respect to determination of death and vital organ transplantation in the case of patients who are irreversibly comatose but remain biologically alive.

This book challenges fundamental doctrines of established medical ethics. It is argued that the routine practice of stopping life support technology causes the death of patients and that donors of vital organs (hearts, liver, lungs, and both kidneys) are not really dead at the time that their organs are removed for life-saving transplantation. Although these practices are ethically legitimate, they are not compatible with traditional medical ethics: they conflict with the norms that doctors must not intentionally cause the death of (...) their patients and that vital organs can be obtained only from dead donors. The aim of this book is to undertake an ethical examination that aims to honestly face the reality of medical practices at the end of life. This involves exposing the misconception that stopping life support merely allows patients to die from their medical conditions, that there is an ethical bright line separating withdrawal of life support from active euthanasia, and that determination of death of hospitalized patients prior to vital organ donation is consistent with the established biological conception of death. A novel ethical justification is required for procuring vital organs from still-living donors. It is contended that in the context of plans to withdraw life support, donors of vital organs are not harmed or wronged by organ procurement prior to death, provided that valid consent is obtained for stopping treatment and organ donation. In view of serious practical difficulties in facing the truth regarding organ donation, an alternative pragmatic account is developed for justifying current practices that relies on the concept of transparent legal fictions. In sum, it is the thesis of this book that to preserve the legitimacy of end-of-life practices, we need to reconstruct medical ethics. (shrink)

We seek to change the conversation about brain death by highlighting the distinction between brain death as a biological concept versus brain death as a legal status. The fact that brain death does not cohere with any biologically plausible definition of death has been known for decades. Nevertheless, this fact has not threatened the acceptance of brain death as a legal status that permits individuals to be treated as if they are dead. The similarities between “legally dead” and “legally blind” (...) demonstrate how we may legitimately choose bright-line legal definitions that do not cohere with biological reality. Not only does this distinction bring conceptual coherence to the conversation about brain death, but it has practical implications as well. Once brain death is recognized as a social construction not grounded in biological reality, we create the possibility of changing the social construction in ways that may better serve both organ donors and recipients alike. (shrink)

Bioethics is a hybrid discipline. As a theoretical enterprise it stands for untrammeled inquiry and argument. Yet it aims to influence medical practice and policy. In this article we explore tensions between these two dimensions of bioethics and examine the merits and perils of a “Socratic” approach to bioethics that challenges “the conventional wisdom.”.

The American Journal of Bioethics, Volume 12, Issue 6, Page 10-11, June 2012.

Human life and death should be defined biologically. It is important not to conflate the definition of death with the criteria for when it has occurred. What is distinctively "human" from a scientific or normative perspective has nothing to do with what makes humans alive or dead. We are biological organisms, despite the fact that what is meaningful about human life is not defined in biological terms. Consequently, as in the rest of the realm of living beings, human beings die (...) when they no longer function biologically as organisms. In contrast, a determination of exactly when death has occurred, required to serve various social purposes, combines social and normative considerations with biological facts. (shrink)

Mood disorders, including major depressive disorder and bipolar disorder, are highly prevalent, frequently disabling, and sometimes deadly. Additional research and more effective medications are desperately needed, but clinical trials research in mood disorders is fraught with ethical issues. Although many authors have discussed these issues, most do so from a theoretical viewpoint. This manuscript uses available empirical data to inform a discussion of the primary ethical issues raised in mood disorders research. These include issues of consent and decision-making capacity, including (...) patients’ motivations for participating in research. We also address drug withdrawals, placebo controls, and the overall safety of research. Finally, we examine the extant literature for studies discussing potential indirect benefits of clinical trials research to participants. Taken together, the evidence suggests that clinical trials research incorporating drug withdrawals and placebo controls can be conducted safely and ethically, even in patients with severe or treatment-resistant mood disorders. In fact, given the dearth of effective treatment options for this population, it is our opinion that a moral imperative exists to extend the offer of research participation to severely ill or treatment-resistant groups. (shrink)

On July 16, 1938, Franklin Delano Roosevelt boarded the USS Houston in San Diego and embarked on what would come to be known as the Third Presidential Cruise. Publicized as a presidential fishing trip, the 1938 excursion was considerably more than a summer vacation. Covering 5,888 miles in twenty-four days, it comprised fourteen stops in the territories of five different countries: Mexico, France, Ecuador, Costa Rica, and Colombia. Concluding in Pensacola, Florida, after passing through the Panama Canal, it (...) was an ambitious voyage that involved the intensive use of science as diplomacy, a mere thirteen months before the onset of World War II. On the surface, the cruise, whose collecting activities were supervised by the Smithsonian’s Division of Marine Invertebrates, was a major scientific coup. However, the expedition also had a clear geopolitical goal: to assess the United States’ naval capabilities in the Pacific and to formulate potential military strategies in the event of global war. Thus, the excursion illustrates how science and diplomacy can intersect at pivotal historical moments, and how it can be deployed to implement foreign policy based on military interests. (shrink)

Although informed consent is important in clinical research, questions persist regarding when it is necessary, what it requires, and how it should be obtained. The standard view in research ethics is that the function of informed consent is to respect individual autonomy. However, consent processes are multidimensional and serve other ethical functions as well. These functions deserve particular attention when barriers to consent exist. We argue that consent serves seven ethically important and conceptually distinct functions. The first four functions pertain (...) principally to individual participants: (1) providing transparency; (2) allowing control and authorization; (3) promoting concordance with participants' values; and (4) protecting and promoting welfare interests. Three other functions are systemic or policy focused: (5) promoting trust; (6) satisfying regulatory requirements; and (7) promoting integrity in research. Reframing consent around these functions can guide approaches to consent that are context sensitive and that maximize achievable goals. (shrink)